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LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor, and can induce TrkB, TrkC, AKT and ERK activation in vitro and in vivo. LM22B-10 exhibits maximum neurotrophic survival activity levels that are higher than those …

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Biological Activity for LM22B 10. LM22B 10 is a TrkB and TrkC agonist. Exhibits neurotrophic activity (EC 50 = 200-300 nM), improves survival and increases neurite outgrowth in hippocampal cells in vitro. Exhibits no significant activity in a screen of 57 other receptors and transporters. Inhibits binding of BDNF and neurotrophin-3 to TrkB and ...

1. Introduction. The cornea is one of the most sensitive tissues in the body and contains a large number of nerve fibers. It has been reported that the density of corneal pain receptors is 300–600 times higher than that of skin and 20–40 times higher than that of the dental pulp [].The sensory nerves from the trigeminal nerve pass through the anterior stroma radially …

LM22B-10. ：S6760. . LM22B-10 TrkB/TrkC,LM22B-10 TrkB 、 TrkC 、 AKT ERK …

LM22B-10 is a brain penetrant, potent and selective TrkB and TrkC neurotrophin receptors agonist that improves cell survival and potently accelerated neurite outgrowth. LM22B-10 inhibits binding of BDNF to TrkB-expressing cells and NT-3 to TrkC-expressing cells. Safety Information.

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LM22B-10-34 | LM22B-10 is an activator of TrkB/TrkC neurotrophin receptor and can induce TrkB, TrkC, ERK and AKT activation in vitro and in vivo.HPLC、LCMS、HNMR,。

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LM22B-10. LM22B-10 TrkB/TrkC, TrkB,TrkC,AKT ERK 。. LM22B-10BDNF（0.7 nMBDNF 53±7.2％）NT …

LM22B-10 (250-2000 nM) binds to TrkB-Fc and TrkC-Fc in a dose-dependent manner. LM22B-10 inhibits binding of BDNF to TrkB-expressing cells and NT-3 to TrkC-expressing cells. LM22B-10 promotes cell survival and functions preferentially through TrkB and TrkC. LM22B-10, but not BDNF or NT-3, promotes neurite outgrowth in an inhibitory environment.

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Then, LM22B-10, an activator of the NT-3 receptor TrkB/TrkC, can also activate ERK-CREB to enhance nerve growth. After administering LM22B-10 eye drops to regular and diabetic mice with corneal wounding, LM22B-10 significantly improves the healing speed of the corneal epithelium, corneal sensitivity, and corneal nerve density. ...

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LM22B-10 is an activator of neurotrophic tyrosine kinase receptor 2 (TrkB) and -3 (TrkC). 1 It is selective for TrkB and TrkC over TrkA in NIH3T3 cells but does inhibit the serotonin (5-HT) receptor subtype 5-HT 5A and the dopamine transporter by greater than 50% in a panel of 57 G protein-coupled peptide and nonpeptide receptors at 10 µM. LM22B-10 increases survival, …

LM22B-10. Catalog No.S6760. For research use only. LM22B-10 is a small molecule TrkB/TrkC neurotrophin receptor co-activator, LM22B-10 selectively activates TrkB, TrkC, AKT and ERK in vivo and in vitro. CAS No. 34.

LM22B 10 is a TrkB and TrkC agonist. Exhibits neurotrophic activity (EC 50 = 200-300 nM), improves survival and increases neurite outgrowth in hippocampal cells in vitro. Exhibits no significant activity in a screen of 57 other receptors and transporters. Inhibits binding of BDNF and neurotrophin-3 to TrkB and TrkC, respectively.

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E Western blot of ERK and EMT markers expression in AGS, Hs746T and BGC-823 cells transfected with shTNC and treated with LM22B-10. F qPCR analysis of MMP2/9 in AGS, BGC-823 and Hs746T cells ...

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It increases cell survival and accelerates neurite outgrowth. LM22B-10 supports substantial early neurite outgrowth in the presence of inhibiting glycoproteins. In aged mice, it (50 mg/kg/day i.p. in combination with an intranasal dose of 5 mg/kg/day for 30 days) activates hippocampal and striatal TrkB and TrkC, their downstream signaling and ...